FerriScan is useful for both the detection and monitoring of iron overload, a measurement of LIC is considered necessary in most instances for the detection of iron overload and to assist with a clinical diagnosis. Following detection of iron overload, the duration of de-ironing therapy may be predicted on the basis of the liver iron concentration. FerriScan utilises MRI, which is readily available and internationally recognised as a safe imaging modality.

FerriScan is the world's first regulated, non-invasive liver iron concentration test for people suffering from iron overload conditions. The test offers these people a safe, fast and most importantly accurate determination of their liver iron levels. FerriScan enables patients and clinicians to plan and monitor their treatment more effectively.

Currently the scanner MUST have a 1.5T magnet. The FerriScan technology has not yet been extended to scanners with other field strengths.

FerriScan is a post-image processing service that returns a liver iron concentration measurement. As inputs it requires 5 single spin echo series of axial images with TR = 2500ms and TEs of 6ms, 9ms, 12ms, 15ms and 18ms respectively. The report returned contains a liver iron concentration expressed in two different units (mg of iron / g of liver tissue dry weight and mmol of iron / kg of liver tissue dry weight) and as an age adjusted measure (mmol/kg/year).

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FerriScan is a new technology for the non-invasive measurement of liver iron concentration (LIC). Advanced computer software, the result of extensive research and trials, is used to analyse data obtained through magnetic resonance imaging (MRI) of a patient's liver to determine an accurate measurement of liver iron concentration. The image data collected from the MRI scans is then sent electronically to the FerriScan Service Centre where it is analysed using the FerriScan technology.

FerriScan has regulatory clearances in Australia, Euope and the USA and is now available as a commercial service.

For a clinician to refer a patient, they will need to either (a) tick or write FerriScan; or (b) indicate a request for MRI liver iron concentration measurement on the radiology referral form.

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Patients should not eat any food 3 to 4 hours before the FerriScan MRI scan. Other than that patients may drink normally and continue to take any medications prescribed by their clinician. Patients should also remember to bring their referral form with them to the MRI centre.

More information on FerriScan or Resonance Health is available by downloading brochures from our website or by emailing any further questions to info@ferriscan.com.

FerriScan should work with any phased-array receiver coil for torso imaging. Previous experience has shown torso/abdominal coils and 8 channel cardiac array coils are compatible with FerriScan. Currently the main housing coil does not provide sufficient signal to noise for use as the receiver for FerriScan data acquisition.

Ferriscan can accept data that is de-identified, provided that the anonymised fields match between the DICOM header and the online Job Request system. The name field and DOB fields should be de-identified rather than omitted from images (age in years is required to calculate the hepatic iron index). Scanner specific information must be retained to confirm the scanners validity with Ferriscan (i.e. device serial number and organisation name must be retained).

Common times for acquiring a single series is 3 ? to 4 minutes, resulting in a total scan time of 17 ? to 20 minutes ignoring scout/localiser scans and setup time.

To obtain optimal sensitivity and specificity over a large range of liver iron concentrations the fundamental 1/T2 value needs to be measured rather than 1/T1 or 1/T2*. This necessitates a long TR to minimise T1 effects and prevents the use of a breath-hold scan. As a result, modest breathing artefacts are expected and are compensated for during the FerriScan Analysis.

Scanners commonly in use with FerriScan include: Siemens Avanto, Siemens Symphony, Siemens Sonata and Philips Intera. GE scanners currently require a research sequence to attain the required performance, which is obtainable only through GE representatives. Currently Picker and Shimadzu-Marconi scanners are not supported for use with FerriScan.

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The FerriScan Analysis process has multiple steps to determine the fundamental 1/T2 values of tissue. Critical to the analysis are: the use of an external reference (saline infusion bag); the sampling of structured and unstructured noise from spaces all around the patient; and the measurement of the RF signal attenuation profile through the entire cross section of the patient.