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Why is the PSA test controversial?

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Using the PSA test to screen men for prostate cancer is controversial because it is not yet known if the process actually saves lives. Moreover, it is not clear if the benefits of PSA screening outweigh the risks of follow up diagnostic tests and cancer treatments. The procedures used to diagnose prostate cancer may cause significant side effects, including bleeding and infection. Prostate cancer treatment often causes incontinence and impotence.
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What is a PSA blood test? PAP?

Prostate Cancer FAQ
The PSA blood test is an important tool in helping to detect prostate cancer, especially when it is done along with a digital rectal examination (DRE). Often, the doctor will order blood tests to measure a substance called prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). The level of PSA in the blood may rise in men who have prostate cancer or benign prostatic hypertrophy.
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What is PSA? How often should I get a test?

PSA - North of England
Prostate Specific Antigen is a protein made by the prostate gland, which naturally leaks out into the bloodstream. The PSA test measures the level of PSA in the blood. The test is not always reliable as PSA levels also increase as men get older and due to other conditions of the prostate.
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What is the PSA test?

Services - FAQs - Vancouver Neurologists, P.S.
Prostate-specific antigen (PSA) is a substance produced by the prostate gland. This is a test that measures the amount of PSA in the bloodstream.
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My wife really wants me to have a PSA test. What is PSA and Should I have the test?

Frequently Asked Questions
A: PSA stands for prostate specific antigen. It is a protein that is produced by normal prostatic cells as well as cancerous prostate cells and is measured with a blood test. In many instances, especially in men where there is a family history of the disease, the higher the PSA, the greater the chances of prostate cancer. If the PSA is "too high" a prostate biopsy may be recommended. Defining what is "too high" depends on age as well as prostate size and previous PSA readings.
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Patients - Product Information
The PSA or prostate specific antigen test is a blood test used to measure the amount of a particular protein found in a person's blood. Prostate cells make this protein and normally the PSA level is usually low (less than 4.0 nanograms per milliliter). Prostate cancer and certain other conditions can raise the PSA value because of an increase in the amount of prostate specific protein circulating in the blood. If the PSA value is higher than 4.
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URF - The Site for Prostate Cancer Information
The PSA blood test is probably the single most accurate test we have for the detection of prostate cancer. PSA is a protein that’s produced in the prostate gland. Normally, the PSA should be very low in the bloodstream. Our studies showed that the median PSA level is 0.7 for men in their 40s, 0.9 for men in their 50s and 1.4 for men in their 60s. If the prostate is diseased – from benign enlargement, inflammation, or prostate cancer – the PSA is elevated.
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How useful is a PSA test once a patient is diagnosed with cancer?

Metropolitan Urology | St. Louis Missouri
PSA is an excellent marker for use during and after cancer therapy. PSA lets the patient know how the cancer is responding to the treatment.
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What happens if the PSA test is abnormal?

Ontario Ministry of Health and Long-Term Care - Health Care ...
If a PSA test is close to the cut-off value, you may decide to repeat it to make sure it is not a laboratory error. You might immediately investigate your patient for prostatic enlargement, infection or cancer if the PSA is above the cut-off value.
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What is the accuracy of the PSA test?

Ontario Ministry of Health and Long-Term Care - Health Care ...
Three men (3/10) will be found to have significant prostate cancer after the first biopsy; i.e., seven men (7/10) will be found not to have prostate cancer at this time (false positives); Over the next several years, another two of these men will have significant prostate cancer detected during follow-up; Over an extended period of time, five of the ten men will be found not to have prostate cancer despite further investigation (false positives).
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Why is the PSA test performed?

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The U.S. Food and Drug Administration (FDA) has approved the PSA test for use in conjunction with a digital rectal exam (DRE) to help detect prostate cancer in men age 50 and older. During a DRE, a doctor inserts a gloved finger into the rectum and feels the prostate gland through the rectal wall to check for bumps or abnormal areas. Doctors often use the PSA test and DRE as prostate cancer screening tests in men who have no symptoms of the disease.
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When should I get a PSA Test and how often is testing done?

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The benefits of screening for prostate cancer are still being studied. The National Cancer Institute (NCI) is currently conducting the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, or PLCO trial, to determine if certain screening tests reduce the number of deaths from these cancers. The DRE and PSA are being studied to determine whether yearly screening to detect prostate cancer will decrease one's chance of dying from prostate cancer.
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How are PSA test results reported?

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PSA test results report the level of PSA detected in the blood. The PSA level that is considered normal for an average man ranges from 0 to 4 nanograms per milliliter (ng/ml). A PSA level of 4 to 10 ng/ml is considered slightly elevated; levels between 10 and 20 ng/ml are considered moderately elevated; and anything above that is considered highly elevated. various factors can cause PSA levels to fluctuate, one abnormal PSA test does not necessarily indicate a need for other diagnostic tests.
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What are some of the limitations of the PSA test?

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Detection does not always mean saving lives: Even though the PSA test can detect small tumors, finding a small tumor does not necessarily reduce a man's chance of dying from prostate cancer. PSA testing may identify very slow-growing tumors that are unlikely to threaten a man's life. Also, PSA testing may not help a man with a fast-growing or aggressive cancer that has already spread to other parts of his body before being detected.
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What research is being done to improve the PSA test?

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Scientists are researching ways to distinguish between cancerous and benign conditions, and between slow-growing cancers and fast-growing, potentially lethal cancers. Some of the methods being studied are: PSA velocity: PSA velocity is based on changes in PSA levels over time. A sharp rise in the PSA level raises the suspicion of cancer. Age-adjusted PSA: Age is an important factor in increasing PSA levels.
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Why is psychobiography controversial?

Psychobiography: FAQ
This is a hard question to give a short answer to. The main reason is because psychology favors quantitative methods, or the reduction of people to numbers of responses. Psychology also privileges the detection of laws and patterns over the detection of uniqueness. Last, psychology likes to think of itself as objective, thus treating the study of the mind as on a par with the study of, say, the tides.
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What is PSA and what is a normal PSA range?

FAQs - TerKeurst Urology Clinic
PSA stands for prostate specific antigen. When the prostate is irritated, inflamed, or damaged, the PSA level in the bloodstream rises. The normal range is usually 0 to 4. There may be some variations of normal range based on age and race.*
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Q: How useful is a PSA test once a patient is diagnosed with cancer and in therapy?

URF - The Site for Prostate Cancer Information
PSA is an excellent marker for use during and after cancer therapy. Ninety-nine percent of the time, PSA lets a patient know how the cancer is responding to the treatment.
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Should I have a PSA test and what will it mean?

BPG Mens Health
Unless you have symptoms of difficulty passing urine, an abnormal-feeling prostate gland, or a strong family history of prostate cancer it is unlikely that your doctor will recommend that you have a PSA test performed. This is partly because of the uncertainties mentioned in the section above. There has been a case put forward for the screening of asymptomatic (without symptoms) men – i.e. looking for possible cancer in men who have absolutely no symptoms at all.
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What is the prostate-specific antigen (PSA) test?

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The prostate-specific antigen (PSA) test measures the level of PSA in the blood. A blood sample is drawn and the amount of PSA is measured in a laboratory. PSA is a protein produced by the cells of the prostate gland. When the prostate gland enlarges, PSA levels in the blood tend to rise. PSA levels can rise due to cancer or benign (not cancerous) conditions. Because PSA is produced by the body and can be used to detect disease, it is sometimes called a biological marker or tumor marker.
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What if the test results show an elevated PSA level?

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A man should discuss elevated PSA test results with his doctor. There are many possible reasons for an elevated PSA level, including prostate cancer, benign prostate enlargement, inflammation, infection, age, and race. If there are no other indicators that suggest cancer, the doctor may recommend repeating DRE and PSA tests regularly to monitor any changes.
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What is PSA?

Arcspan :. FAQ
According to Webopedia, "Professional Services Automation (PSA) refers to a suite of software enabling IT service organizations to manage people and skilled resources." In other words, PSA helps companies to better operate and organize their time, invoicing and billing, expenses, projects, people and more. Click here to see what Arcspan can do for you.
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Will there be more PSA's?

The Three Amigos - FAQ
Subject to funding, the next round of PSA’s will cover more issues and several will be produced on other approaches towards HIV/AIDS prevention.
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What are the controversial/political issues?

American Social Health Association - HPV Resource Center
HPV is a sexually transmitted infection and the vaccine needs to be administered before sexual debut. Teen sexuality has become a political issue in the US. Some groups may oppose vaccination (believing that it would encourage teenage sexual promiscuity). Some groups support the development of vaccines but may create barriers to access. For example, the Family Research Council says it "would oppose any measures to legally require vaccination or to coerce parents into authorizing it.
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Q:Why is it so controversial?

Shroud of Turin - FAQ Frequently Asked Questions Answered He...
Jesus was controversial...he still is! If it was believed to be the image of some unknown murder victim, who would care? But because many believe the cloth bears the markings of Christ's crucifixion and maybe even his resurrection...it will always be controversial no matter what new evidence is found.
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Should I advise my patients to be screened with the PSA test-or not? What do the experts say?

Ontario Ministry of Health and Long-Term Care - Health Care ...
What do I tell my patients if they say, "Isn't finding cancer early supposed to improve my chances of cure?"
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What is the PSA blood test, and how is it used to screen for prostate cancer?

Ontario Ministry of Health and Long-Term Care - Health Care ...
Prostate-specific antigen (PSA) is a protein produced by prostate tissue. An elevated PSA level in the blood may identify the presence of cancerous abnormalities of the prostate gland before symptoms are reported, and thus has been used as a screening test. The limitation of PSA as a diagnostic test is that PSA levels can be elevated in benign diseases of the prostate as well as in malignancies.
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