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What is latent TB infection (LTBI)?

Washington County -- Tuberculosis
In most people who breathe in TB bacteria and become infected, the person's body is able to fight the infection and keep them from growing. The TB bacteria become dormant, and this is called latent TB infection. People with latent TB infection: Many people who have latent TB infection never develop active TB disease. In these people, the TB bacteria remain in the body for a lifetime without causing disease.
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What is the difference between latent TB infection (LTBI) and TB disease?

Public Health | Monroe County, NY
People with latent TB infection test positive on their skin test for TB but they are not sick and they can not spread the disease to anyone else.
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What is latent TB infection?

Tuberculosis (TB) Treatment & Control Clinic - Southern ...
In most people who breathe in TB bacteria and become infected, the body is able to fight the bacteria to stop them from growing. The bacteria become inactive, but they remain alive in the body and can become active later. This is called latent TB infection. Many people who have latent TB infection never develop active TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease.
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What should I do if I have spent time with someone with latent TB infection?

Frequently Asked Questions about Tuberculosis (TB)
A person with latent TB infection cannot spread germs to other people. You do not need to be tested if you have spent time with someone with latent TB infection. However, if you have spent time with someone with active TB disease or someone with symptoms of TB, you should be tested with a skin test.
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Is there a test for latent TB infection?

Oxford Immunotec - FAQs
The most reliable test for latent TB is the recently introduced T‑SPOT.TB test from Oxford Immunotec. An older, alternative test is the Tuberculin Skin Test (TST) which is performed using one of two methods; the Mantoux test or the Heaf test. The latter was used in the UK but has now been phased out in favour of the unlicensed Mantoux test. The T‑SPOT.TB assay is an in vitro diagnostic laboratory test that identifies Mycobacterium tuberculosis infection from a blood sample.
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What should I do if I have TB infection?

Hawaii State Department of Health - www.hawaii.gov/health
If you have TB infection, you need treatment so you will not get TB disease later. This is called preventive therapy. Isoniazid (INH) is the anti-TB drug used most often. Unless you get preventive treatment, TB infection can turn into TB disease. Anyone who is infected can develop TB disease, but those who are more likely include: People with certain medical conditions such as diabetes, certain types of cancers and being underweight; and especially These things make your body weaker.
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Oxford Immunotec - FAQs
When most people become infected with M. tuberculosis their own immune system limits the multiplication of the bacteria preventing the illness from developing. A small proportion of people who get infected are able to kill off the infection naturally. However, in many people the bacteria are not killed but are kept under control by the body's immune system. These people do not have any symptoms and cannot spread the disease. The infection is said to be latent (dormant).
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ID Associates: Tuberculosis
First, a TB skin test is performed. If it is positive, other tests will be performed such as a chest x-ray or sputum sample to see if the person has TB disease. If it is negative it usually means that the person is not infected. However, the test can be falsely negative in the first 2 to 10 weeks after a person has been exposed and so repeat testing may be recommended.
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How is Latent TB Infection Different From TB Disease?

Frequent Questions - Public Health Department (DEP)
Latent TB infection means that a person has breathed in TB bacteria, or germs, and become infected with TB, but their body has been able to fight the infection and keep it from becoming active and making them sick. People with latent TB infection are not contagious and can not give TB to others.
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What is the difference between latent TB infection and TB disease?

ID Associates: Tuberculosis
Latent TB infection results when the TB bacteria live in your body without making you sick. The bacteria lie inactive because the body is able to fight the bacteria to stop them from growing. These people have no symptoms and can’t spread the disease to others. TB disease can result if the bacteria become active when the immune system can’t stop them from growing.
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Who should be screened for latent TB?

Screening Tuberculosis
People who live or work in places where TB is more common, such as homeless shelters, migrant labor camps, prisons, jails, hospitals, and some nursing homes. Patients with HIV, silicosis, malnutrition, renal failure, or other conditions placing them at higher risk for active TB.
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Where Can I get Treatment For Latent TB Infection or Active TB Disease?

Frequent Questions - Public Health Department (DEP)
If you have a regular health care provider, you should see them first. If you don’t have a health care provider, you can receive TB Treatment from the Santa Clara Valley Health and Hospital System TB Clinic. For more information about the TB Clinic see the Related Link below.
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What is the difference between TB disease and TB infection?

TB frequently asked questions
In most people who breathe in TB bacteria and become infected, the body is able to fight the bacteria to stop them from growing. The bacteria become inactive, but they remain alive in the body and can become active later. This is called TB infection. Most people who have TB infection will never develop TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease.
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What is the difference between TB infection and TB disease?

Hawaii State Department of Health - www.hawaii.gov/health
People with TB infection (without disease) have the germ that causes TB in their body. They may have been carrying this germ for a short or a very long time, but they are not sick because the germ lies inactive in the body. The body's strong immune system has the germs under control. While the TB germs are inactive in your body, they cannot hurt you and you cannot spread them to other people. In fact, if you are infected by the TB germs, you probably will not know it and you will not feel sick.
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What is the difference between latent TB and active TB?

Frequently Asked Questions about Tuberculosis (TB)
Latent TB is when the body’s immune system forms a wall around the TB bacteria so the TB bacteria cannot multiply or spread. The TB germs are essentially “asleep” in your body when you have latent TB. A person with latent TB is not contagious (cannot spread TB to other people) and has no symptoms. TB bacteria can stay latent for long periods of time (e.g. from many years to the rest of your life). Active TB is when the body cannot adequately fight the TB bacteria.
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What is the difference between active and latent TB?

Scantibodies Clinical Laboratory - Home Page
Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. TB is spread through the air from one person to another. A person with active TB is contagious and symptoms may include coughing, unexplained weight loss, night sweats, fever, chills, no appetite and fatigue.
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Why treat latent TB?

Latent TB: FAQ's
Completing a course of treatment decreases the person's lifetime risk of developing active TB by 90%. Treatment of latent TB is also a cornerstone of efforts to eliminate TB in society, since it minimizes the number of infectious cases.
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Who should be treated for latent TB?

Latent TB: FAQ's
In general, anyone with a positive TB test who is at high risk of reactivation should be treated, regardless of age. (See above list of high-risk groups). Although the 2000 CDC guidelines seem to suggest that foreign-born persons not be treated if they have been living in the United States more than 5 years, a recent study found that 25% of all cases of active TB in the US occur in this population.
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How is latent TB treated?

Latent TB: FAQ's
Nine months of isoniazid (INH) is the preferred treatment regimen for all cases of latent TB, including HIV patients, pregnant women, and children. A minimum of 270 doses must be administered within 12 months. In pregnancy, it is preferable to wait until the post-partum period to administer INH, unless the mother has HIV or a recent contact with active TB. Breastfeeding is not a contraindication to isoniazid.
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Who gets TB infection?

Public Health | Monroe County, NY
Anyone at any age can become infected with bacteria that cause tuberculosis. Some people at higher risk include: people who have medical conditions which impair their immune systems (i.e., cancer, diabetes, silicosis.)
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How does HIV infection affect TB?

Hawaii State Department of Health - www.hawaii.gov/health
HIV (human immunodeficiency virus, the AIDS virus) helps TB germs make you sick by attacking the germ fighters in your body. If you are infected with HIV and with TB germs, you have a very big chance of getting TB disease. The TB germs are much more likely to attack your lungs and other parts of the body. You can be cured, but it takes longer to cure someone with TB disease who also has HIV infection. If you think you might have HIV infection, talk to your doctor about getting an HIV test.
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If I Have TB Infection, How Can I Keep from Developing TB Disease?

tb.htm
Many people who have TB infection never develop TB disease. But some people who have TB infection are more likely to develop TB disease than others. These people are at high risk for TB disease.
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