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What are the clinical benefits of Sandostatin® for patients with acromegaly?

Sandostatin.com Global for Healthcare Professionals - Freque...
Cardiovascular disease is widely acknowledged as one of the most important complications of acromegaly, accounting for much of the mortality associated with the condition. Long-term studies with both Sandostatin® and Sandostatin® LAR® have shown that normalization of GH and IGF-1 levels is associated with improved cardiac performance in patients with acromegaly.
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Do all patients with acromegaly respond to Sandostatin® treatment?

Sandostatin.com Global for Healthcare Professionals - Freque...
Clinical studies show that Sandostatin® produces a fall in GH serum concentration in approximately 85-90% of patients with acromegaly.30,31 More than 50% of those treated will achieve serum GH levels (5 ?g/L and almost 75% of patients will have normalized IGF-1 levels.32 In a recent study in 42 patients with acromegaly, a single dose of Sandostatin® reduced GH levels from a mean basal level of 26 ?g/L to less than 5 ?g/L in 74% of patients within 6 hours.
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When is it appropriate to treat acromegaly with Sandostatin®?

Sandostatin.com Global for Healthcare Professionals - Freque...
Sandostatin® is typically used as second-line treatment in patients whose GH levels remain elevated after surgery, or in those patients for whom surgical resection is not an option. 5 Based on the results of independent investigations, it has been proposed that it should also be considered as first-line treatment in patients with acromegaly caused by a macroadenoma, in whom the chances of surgical cure are reduced.
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How many patients are using the device? In the US? Elsewhere? In clinical trials?

Alternative Medicine & High Blood Pressure, Natural Remedies...
Although the device represents a new class of treatment, it is not an alternative medicine treatment. Hypertension is a mainstream disorder and RESPeRATE has received clearance from the FDA as an adjunctive treatment for hypertension (together with other pharmacological and/or non-pharmacological interventions.) The device is also validated by numerous published peer reviewed studies and a renowned Scientific Advisory Board.
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What are the benefits to patients?

DigitalDerm, Inc - FAQ
Patients at high risk of melanoma often feel anxious over real and perceived changes in their skin. MoleMapCD allows them to observe, compare and document changes in their skin within the privacy of their homes and call their physicians when a change is detected. Because it provides an accurate baseline of the entire skin surface, MoleMapCD aids the patient in detecting skin changes in its earliest stages thereby alerting their physician to potential melanomas between routine office visits.
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What is acromegaly?

Acromegaly FAQs Medical Reference Medical Encyclopedia Infor...
Acromegaly is a serious condition that occurs when the body produces too much of the hormones that control growth. This causes abnormal enlargement of bone, cartilage, muscle, organs, and other tissues. This abnormal growth can cause serious disease and even premature death.
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What is Sandostatin®?

Sandostatin.com Global for Healthcare Professionals - Freque...
Sandostatin® is a long-acting synthetic analog of somatostatin that binds with maximum affinity to the somatostatin receptor subtype SSTR2, and to a lesser extent to SSTR3 and SSTR5.16 Through this interaction, Sandostatin® exerts a number of physiological effects, including alteration of the expression of several hormones. Of note in acromegaly is the potent suppression of GH release, which is 40- to 70-times more potent than that achieved with somatostatin.
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Are there other Tarceva clinical trials available for patients with advanced NSCLC?

Lung Cancer Frequently Asked Questions - Tarceva.com
You can find information on additional clinical trials of Tarceva (erlotinib) by visiting ClinicalTrials.gov
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What types of cancers did patients have in registrational clinical trials?

About Kepivance®: Frequently Asked Questions
All patients had hematologic malignancies including non-Hodgkin's lymphoma, Hodgkin's disease, acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, or multiple myeloma.
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How are patients with acromegaly refractory to surgical intervention managed?

Sandostatin.com Global for Healthcare Professionals - Freque...
For patients with acromegaly who are not candidates for surgery, or for whom surgery is unsuccessful, alternative approaches, such as irradiation and pharmacological therapy, are required. In recent years, the use of pituitary irradiation has declined. The technique is commonly associated with adverse effects, including hypopituitarism.
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What are the benefits and risks of participating in a clinical trial?

Clinical Trial FAQ's
Clinical trials that are well-designed and well-executed are the best approach for eligible participants to: The protocol may require more of their time and attention than would a non-protocol treatment, including trips to the study site, more treatments, hospital stays or complex dosage requirements.
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What are the potential benefits of participating in a clinical trial?

Clinical Trials - Frequently Asked Questions - sleepdisorder...
Clinical trials allow access to new treatments before they become available to the public and allow you to expand your treatment options. Clinical trials provide an opportunity to contribute to science and medical research for future disease prevention and treatment.
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Are there long-term benefits of clinical trials?

Frequently Asked Questions-Clinical Trials-PPediatric Care
Clinical trials are important in the long-term treatment of childhood cancer, and discoveries made years ago through clinical trials are now the standard of care for conditions like leukemia and lymphoma. By participating in a trial, your child will help us develop improved treatments for future children with the same condition.
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What are the expected benefits to patients?

NCI Community Cancer Centers Program - Frequently Asked Ques...
The sites will provide patients with comprehensive cancer screening, prevention, treatment, and palliative care. Patients diagnosed with cancer will receive medical, surgical, and radiation oncology services and will have access to NCI-sponsored clinical trials. In addition, NCI-trained patient navigators will assist patients in arranging financial support, scheduling transportation services, coordinating records transfers, and facilitating access to other services.
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Are any clinical studies of PTC124 currently recruiting patients?

PTC Therapeutics
No new Phase 2a trials are currently planned in Duchenne muscular dystrophy. We have initiated a new Phase 2a study in cystic fibrosis at Hôpital Necker-Enfants Malades, in Paris, France. An additional site in Belgium may join the French study. The study is similar in design to the recently completed Phase 2 cystic fibrosis studies and will enroll patients 6 years of age and older. Please visit www.clinicaltrials.
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What are clinical trials, and how do they affect mesothelioma patients?

Mesothelioma FAQ: Mesothelioma Treatment, Pleural Mesothelio...
A clinical trial is a research study using volunteers. A clinical trial tests the effectiveness and safety of a new procedure or drug, including proper dosage and side effects. Taking part in a clinical trial may prolong or improve a mesothelioma patient’s life. On the other hand, clinical trials deal with experimental drugs or procedures that may have negative results or be ineffective.
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What are the benefits of participating in a clinical trial?

Frequently Asked Questions About Research - Norton Healthcar...
Gain access to new research treatments before they are widely available. Obtain expert medical care at leading health care facilities during the trial. Help others by contributing to medical research. Play an active role in your own health care.
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What are the benefits of clinical hypnosis for children?

Jefflazarusmd.com - Frequently Asked Questions - Using clini...
Teaching children a skill, and not just merely giving them a pill, is very empowering. It shows them that they have the ability and power to gain control over their bodies and life challenges. This raises self-esteem and awareness, builds confidence and gives a sense of mastery and hope. Plus, it's fun!
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How does PTC Therapeutics identify patients with nonsense mutations for the clinical trials?

PTC Therapeutics
To confirm the diagnosis of a nonsense mutation for the clinical trials in cystic fibrosis, PTC Therapeutics employed the gene sequencing test offered by Ambry Genetics (www.ambrygen.com). For the clinical trial in Duchenne muscular dystrophy, we used the test offered by the University of Utah (http://www.genome.utah.edu/DMD/clinical_test.shtml).
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Do cancer patients ever receive placebos (inactive medicines) in a clinical trial?

Brian Nelson
Cancer patients in a clinical trial always receive the best standard treatment available or a new treatment that researchers believe is as good or better. A placebo is a substance that looks like medicine, but is not. Cancer patients are given placebos in a randomized trial only under unusual circumstances.
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How do M. D. Anderson patients pay for clinical trials?

Brian Nelson
The clinical trial sponsor (whether it is the government or a company) may pay for the experimental treatment, special testing, extra doctor visits, travel time and travel expenses. Some health insurance companies also will cover routine costs in clinical trials. Some health insurance companies will cover the costs of procedures that patients would have even if they were not in a clinical trial (routine costs).
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What is expected of patients in a clinical trial?

Clinical Trials in Vision Research [NEI Clinical Studies]
Patients in a clinical trial are expected to have eye exams and other tests. You may also need to take medications and/or undergo surgery. Depending upon the treatment and the examination procedure, you may need a hospital stay. You may have to go back to the medical facility later for followup examinations. These exams help find out how well the treatment is working. Followup studies can take months or years.
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Do patients only receive clinical treatment and education?

MCES patients are also provided with creative arts (e.g., painting or music) therapy and recreational therapy. There are also indoor and outdoor recreational activities. Patients have time for TV, listening to CDs, and reading, if they wish.
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How many patients are enrolled in this trial, and at how many clinical centers?

SCD-HeFT: Statistics for sudden cardiac death and FAQs on la...
There are 2,521 patients enrolled in the trial, at 148 centers across the U.S., Canada (10), and New Zealand (1).
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Frequently Asked Questions About Clinical Trials – Nov...
Clinical trials that are well-designed and well-executed are one of the ways an eligible participant can: The protocol may require more of their time and attention than would a non-protocol treatment, including trips to the study site, more treatments, hospital stays or complex dosage requirements.
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Frequently Asked Questions - The Children's Hospital, Colora...
Benefits: Clinical trials that are well-designed and well-executed are the best approach for eligible participants to: They study may require more of their time and attention, including trips to the study site, more treatments, or complex dosage requirements.
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