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See also: Is Ewing's sarcoma a childhood or an adult disease ?

Ewings Sarcoma FAQ - CancerIndex
Are my relatives at risk ? Almost all Ewing's sarcoma tumours have a change in their genetic makeup. Normal human cells contain 23 pairs of chromosomes. In Ewing's sarcoma tumours, a piece of chromosome 11 has moved to chromosome 22. This creates a new piece of DNA. This does not mean that the disease is passed from parent to child. For genetic change to pass from parent to child, it must be present in the sperm or egg which give rise to a new human being.
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What is Ewing Sarcoma?
Approximately half of all people with Ewing's sarcoma of bone are under 15 years of age at diagnosis. However, it is also common in young adults. The peak ages are between 10 and 20. It is less common before the age of 5 and after the age of 30. Sometimes young adults may be treated by a "paediatric" oncologist because of the doctor's experience with treating this type of cancer.
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FAQ: Ewings sarcoma, childhood cancer, and medical malpracti...
Approximately half of all people with Ewing's sarcoma are under 15 years old at diagnosis. However, it is also common in young adults. The peak ages are between 10 and 20. Ewing’s sarcoma is less common before the age of 5 and after the age of 30.
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Ewings Sarcoma FAQ | Ewing's Sarcoma Fund
Are my relatives at risk? Almost all Ewing's sarcoma tumours have a change in their genetic makeup. Normal human cells contain 23 pairs of chromosomes. In Ewing's sarcoma tumours, a piece of chromosome 11 has moved to chromosome 22. This creates a new piece of DNA. This does not mean that the disease is passed from parent to child. For genetic change to pass from parent to child, it must be present in the sperm or egg which give rise to a new human being.
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See also: How is Ewing's sarcoma diagnosed ?

Ewings Sarcoma FAQ - CancerIndex
How is Ewing's sarcoma diagnosed ? If a bone tumour is suspected the doctor will do a complete medical examination. This may include a blood test as bone tumours can be associated with increased levels of certain enzymes in the blood. The doctor may also recommend X-rays and other scans of the bone(s), if X-rays and scans suggest that a tumour might be present then a biopsy (removal of a sample of tissue) will be performed.
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See also: What are the symptoms of Ewing's sarcoma ?

Ewings Sarcoma FAQ - CancerIndex
What is the treatment for Ewing's sarcoma ? Ewing's sarcoma is usually sensitive to chemotherapy and radiotherapy. Modern treatments are based on chemotherapy combined with local therapy (surgery and/or radiotherapy to the main tumour): Chemotherapy is given to kill malignant cells that may be circulating around the body. It is generally administered before and after the local therapy.
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See also: What is the treatment for Ewing's sarcoma ?

Ewings Sarcoma FAQ - CancerIndex
In young people, the development of the tumour appears to be in some way related to periods in life with rapid growth, hence the average for tumour development is 14-15 years. The relationship to growth may also be part of the explanation why Ewing's sarcoma is slightly more common in boys than in girls. However, Ewing's sarcoma remains an extremely rare tumour in all groups of the population, and there is no extra cause for concern in rapidly growing teenagers.
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Who was Ewing's sarcoma named after ?

Ewings Sarcoma FAQ - CancerIndex
James Ewing, 1866-1943, first described the tumour that was to be named after him in the 1920's. It was Ewing's work which established that the disease was separate from lymphoma and other types of cancer know at that time. Ewing was originally born in Pittsburgh and embarked on his medical career in 1888. In 1899 he was appointed as the first Professor of Pathology at Cornell University where he developed a keen interest in cancer.
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What is Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
Ewing's sarcoma is a type of cancer that can start in either the bone or in nonbony, or soft, tissues. Ewing's sarcoma is part of the Ewing's family of tumors (EFT).Tumors in the soft tissue are called extraosseus. Another member of the EFT family is primitive neuroectodermal tumor (PNET). These cancers are closely related. Doctors believe they come from the same type of cells and they are treated in a similar way.
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See also: Is primitive neuroectodermal tumour (PNET) different to Ewing's sarcoma ?

Ewings Sarcoma FAQ - CancerIndex
What are the symptoms of Ewing's sarcoma ? Symptoms of Ewing's sarcoma vary from person to person and depending on the location and size of the cancer. The most common symptoms are pain and swelling or tenderness in the affected area. Pain may become very intense when the tumour is located near important nerves, like in the sacrum, pelvis or spine. Swelling is often seen, especially when the log bones of the arms or legs are affected.
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Who gets Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
Most people who get Ewing's sarcoma are between 10 and 20 years old. A small number of adults also get this cancer. More males get it than females, and more white people get it than black people. Only 2% to 3% of all childhood cancers are Ewing's sarcoma. Doctors are not sure why one person gets it and another does not.
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Should everyone get a second opinion for Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
Many people with cancer get a second opinion from another doctor. There are many reasons to get one. Here are some of those reasons. Many people are not sure which Ewing's sarcoma treatment would be best for them. It may help to have a second doctor review the diagnosis and treatment options before starting treatment. In most cases, a short delay in treatment will not lower the chance that it will work.
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How can someone get a second opinion for Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
Ask a primary care doctor. He or she may be able to suggest a specialist. This may be a surgeon, medical oncologist, or radiation oncologist. Sometimes these doctors work together at cancer centers or hospitals. Call the National Cancer Institute's Cancer Information Service. The number is 1-800-4-CANCER (1-800-422-6237). They have information about treatment facilities. These include cancer centers and other programs supported by the National Cancer Institute.
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What's new in Ewing's sarcoma research?

Frequently Asked Questions about Ewing's Sarcoma
Cancer research should give you hope. Doctors and researchers around the world are learning more about what causes Ewing's sarcoma. They are finding better ways to prevent it. And they are finding better ways to detect and treat this cancer. Scientists are working on new ways to diagnose the Ewing's family of tumors. They are using special proteins, called antibodies, to look for substances in Ewing's tumors that are not found in any other kind of tumor.
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What is Ewing's sarcoma / PNET?

What is Ewing Sarcoma?
Ewing's sarcoma is a cancer. The cancer can start in bone or in soft tissues. The most common sites for Ewing's sarcoma are the pelvis, the thigh, and the trunk of the body. The peak ages are between 10 and 20, but younger children and older adults can also get Ewing's sarcoma. We do not know exactly what kind of cell gives rise to Ewing's sarcoma. It has some features that resemble the early cells that would normally develop into part of the nervous system.
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Which bones can be affected by Ewing's sarcoma?

What is Ewing Sarcoma?
The most frequent locations for the primary tumour are the pelvis, femur (thigh bone), tibia / fibula (bones of the lower leg), bones of the spine, ribs and humerus (upper arm). Other sites are less common, however, Ewing's sarcoma can potentially arise in any of the 206 bones in the body. It can also develop in the soft tissues without bone involvement. The figure below gives a summary of primary tumour site in a series of over 900 people diagnosed with Ewing's sarcoma of bone.
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What is the cause of Ewing's sarcoma?

What is Ewing Sarcoma?
In young people, the development of the tumour appears to be in some way related to periods in life with rapid growth, hence the average for tumour development is 14-15 years. The relationship to growth may also be part of the explanation why Ewing's sarcoma is slightly more common in boys than in girls. However, Ewing's sarcoma remains an extremely rare tumour in all groups of the population, and there is no extra cause for concern in rapidly growing teenagers.
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Q:What are the risk factors for Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
No lifestyle risk factors have been identified for Ewing's sarcoma. Studies of children with this cancer have found no link between chemicals, radiation, or other exposure. Ewing's sarcoma does not seem to run in families.
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What should I know about clinical trials for Ewing's sarcoma?

Frequently Asked Questions about Ewing's Sarcoma
Clinical trials study new kinds of cancer treatments. Doctors use clinical trials to learn how well new treatments work and what their side effects are. Promising treatments are ones that work better or have fewer side effects than the current treatments. People who participate in these studies get to use treatments before the U.S. Food and Drug Administration (FDA) approves them. People who join trials also help researchers learn more about cancer and help future people with cancer.
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How does the Ewing's sarcoma spread through the body?

What is Ewing Sarcoma?
Ewing's sarcoma spreads when tumour cells enter the blood supply and are circulated to other parts of the body where they may form secondary tumours ("metastases"). Chemotherapy is given to kill these circulating tumour cells. The most common sites for secondary tumours are the lungs and other bones. Tumour cells may also spread via the lymphatic system (this is a network of lymph glands around the body).
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