What are the Symptoms of PKD?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...PKD itself has no symptoms. Only when PKD has progressed to the point of causing renal failure will symptoms occur, and those symptoms will be those associated with renal failure, and not PKD specific. quot;Many cats with PKD will never develop kidney failure so they will have no physical symptoms at all. Their routine blood tests will be normal. Other cats will develop kidney failure, depending on the severity of their disease and how rapidly the cysts grow.
Related QuestionsWhat is PKD?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...PKD (Polycystic Kidney Disease) is a progressive, genetic disease of the kidneys. It occurs in humans, cats, dogs, and other animals. PKD is characterized by the presence of multiple cysts in each Kidney (i.e, bilateral). (See also Is a Single Cyst in One Kidney Conclusive for PKD? and Can Kidney Cysts be Caused by Something Other Than PKD?, below). Research at Ohio State University conducted by Dr.
Related QuestionsHow is PKD Inherited?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...In humans, there are two modes of inheritance: autosomal dominant and autosomal recessive (with at least two, and possibly three different autosomal dominant forms of PKD caused by different genes at different loci). To date, only the autosomal dominant form has been identified in cats. To quote Dr. DiBartola, Professor of Veterinary Clinical Sciences at The Ohio State University College of Veterinary Medicine, and Co-Editor of the Journal of Veterinary Internal Medicine (one of the Dr.
Related QuestionsHow is PKD Diagnosed?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Currently, the best method to diagnose PKD in living cats is by ultrasounding the kidneys. Other radiological modalities have been used, but have proven to be generally less accurate and more costly. However, even the most skilled sonographer using the best equipment cannot be 100 percent accurate in diagnosing PKD via ultrasound, since the resolution afforded by ultrasound is not sufficient to detect very small cysts.
Related QuestionsDo PKD Positive Homozygotes Exist?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...To date, there is no proof whether PKD positive homozygotes (PP) exist or not. We may not know the answer to this question until a DNA test is available and that test has been used on a significant number of PKD positive cats. quot;In all likelihood, the homozygous state (PP) for ADPKD probably is not viable.
Related QuestionsIs PKD Sex Linked?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Based on Dr. Biller's research, and reports from more than 5,000 ultrasounds worldwide since April, 1998, PKD does not appear to be sex linked. Therefore, males and females can both have PKD, and can both pass PKD on to their offspring.
Related QuestionsIs PKD Only a Problem for Persian Breeders?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...No. Although PKD appears to be more prevalent among Persians (including Himalayans) and Exotics, ultrasound results to date have also found PKD in American Curls, American Shorthairs, Siamese and Scottish Folds, as well as Household Pets, Domestic Shorthairs, and Feral cats. An Oriental Shorthair was also diagnosed with PKD as the result of a necropsy.
Related QuestionsCan Any Vet Test for PKD?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Although anyone with access to ultrasound equipment and minimal knowledge of ultrasound can do the testing, the quality and accuracy of the test results appear to be directly proportional to the skill, training, and experience of the sonographer doing the testing. Ultrasound testing can be expensive (as high as $275 US per cat in some private practices, and $25 to $50 US per cat in special PKD "Clinics").
Related QuestionsCan Kidney Cysts be Caused by Something Other Than PKD?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Yes. However, cysts in non-Persian cats are relatively rare, regardless of the cause. So the current theory is that almost all cysts found in Persians and related breeds will be PKD cysts. Dr. Biller will be conducting research to help establish exactly how frequently cysts are found in non-persian cats. This study should help us understand the frequency of non-PKD kidney cysts in Persians, and possibly even provide clues about how they can be differentiated from PKD cysts using ultrasound.
Related QuestionsIs PKD Confined to Certain Lines?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...No, at least not in Persians. PKD positives have been found in virtually all major lines of Persians. However, it is at least possible that a few lines with very small gene pools, particularly if they are not descended from the hand-full of pre-potent cats upon which many of today's Persians owe their lineage, may not have PKD in those lines. However, it is also important to note that virtually all major lines of Persians have PKD negative cats too.
Related QuestionsIs PKD Linked to Certain Colors?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...No. All evidence to date suggests that there is no relationship between a cat's color and the presence or frequency of PKD.
Related QuestionsIs PKD Fatal? If So, Is It Always Fatal?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...If a normal cat lived forever, PKD cats would eventually progress to the point where renal failure occurs, and would eventually die of renal failure. However, in real life, it is believed that most PKD cats actually die from something other than renal failure due to PKD. So the practical answer to this question is no, most PKD positive cats will not die from PKD. However, as Dr. DiBartola notes in a private e-mail, in the Ohio study he and Dr.
Related QuestionsIs There a Cure for PKD -- Or at Least a Treatment?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...There is currently no known cure for PKD, in cats or in humans. While a Kidney Transplant may eliminate the cysts and allow a particular individual to live symptom free, the underlying genetic makeup for that individual is still one of a PKD positive, and that individual can still pass the disease on to its offspring. Similarly, dialysis can replace the function of failed kidneys, but does not change the underlying disease state.
Related QuestionsWhy Are Some Catteries Unscathed by PKD?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Based on all available information, not many Persian catteries of any size have zero positives, at least unless they've already tested and eliminated positives from their breeding program. So if "unscathed" means "no PKD positives", the answer is that not many catteries are unscathed. And because we've never been able to identify PKD positives before, the only reason any cattery would be unscathed is pure, blind luck.
Related QuestionsAre There Catteries That Truly Do Not Have A PKD Problem? If So, Why?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...Why? Because PKD is a genetic disease, not a communicable disease. So any cattery lucky enough to have only PKD negative foundation stock AND never bring in a PKD positive cannot produce PKD positive cats, and thus will be a PKD free cattery.
Related QuestionsAre There Catteries That Have PKD Positive Cats, But Don't Realize They Have PKD? If So, Why?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...PKD expresses itself differently in each cat. And, based on the best information available, it appears that most PKD positive cats die from other reasons -- not from End Stage Renal Failure resulting from PKD. So it is entirely possible to have PKD positives and never have a cat exhibit the signs of renal failure, much less die from PKD. PKD can only be detected by ultrasound or necropsy. Most if not all PKD cases would be picked up on necropsy with histopathology, if that were routinely done.
Related QuestionsAre There Catteries That Have Tested For PKD and Have Reported No PKD Positive Cats?
The Feline PKD FAQ -- Answers to Frequently Asked Questions ...There's a useful web site which reports statistics on PKD testing to date. Although I'm sure there are many catteries who, for one reason or another, have chosen not to report their results, I find this the best source of information currently available. Taking the stats for US Catteries through 10/8/98 and using MS Excel to manipulate the data, I came up with the following information: Slightly less than one half of the US cats tested are included in the Cattery stats (1547 vs.
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