How does Tarceva work?
Lung Cancer Frequently Asked Questions - Tarceva.comTarceva is a targeted cancer treatment. Unlike many traditional chemotherapies, Tarceva affects certain cancer cell activities. Tarceva is designed to block tumor cell growth by targeting the protein in your body called the Human Epidermal Growth Factor Receptor 1 (HER1/EGFR). This protein is important for tumor cell growth in NSCLC.
Related QuestionsWhat is Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comTarceva is a pill taken by mouth once a day to treat your cancer. Tarceva is used for patients with advanced NSCLC who have received at least one previous chemotherapy regimen that did not work. Take Tarceva at least one hour before or two hours after eating.
Related QuestionsWhat are Tarceva's benefits?
Lung Cancer Frequently Asked Questions - Tarceva.comTarceva is an FDA-approved targeted cancer therapy clinically proven to help some NSCLC patients live significantly longer. In addition to improving survival, Tarceva may slow or stop the growth of cancer - and may even shrink the tumors in some patients. Tarceva is convenient to take; it's a pill you take by mouth once a day as prescribed by your doctor. Individual results may vary. Though individual results may vary, Tarceva has been shown to help some patients live longer.
Related QuestionsWhat are Tarceva's indications?
Resources - Frequently Asked Questions - Tarceva.comTarceva monotherapy is indicated for the treatment of patients with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) after failure of at least one prior chemotherapy regimen. Results from two multicenter, placebo-controlled, randomized, Phase III trials conducted in first-line patients with locally advanced or metastatic NSCLC showed no clinical benefit with the concurrent administration of Tarceva with platinum-based chemotherapy, and its use is not recommended in that setting.
Related QuestionsHow do I dose Tarceva?
Resources - Frequently Asked Questions - Tarceva.comSince food substantially increases the bioavailability of erlotinib and may increase the risk of adverse events, patients should be instructed to take Tarceva at least one hour before or two hours after the ingestion of food. The degree that food increases the bioavailability of erlotinib may vary; therefore, Tarceva tablets should be taken on an empty stomach to help ensure that patients obtain consistent plasma levels of the drug.
Related QuestionsHow do I know if I am a candidate for Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comIf you have locally advanced or metastatic NSCLC and have received at least one chemotherapy regimen that has not worked, you may be a candidate for Tarceva. Speak with your doctor about whether Tarceva is right for you.
Related QuestionsWhen in my treatment regimen can Tarceva be used?
Lung Cancer Frequently Asked Questions - Tarceva.comTarceva is approved as monotherapy, meaning it is used without chemotherapy, for second- and third-line treatment of advanced NSCLC patients. This means that your doctor can prescribe Tarceva after one chemotherapy regimen has not worked.
Related QuestionsWhat common side effects may I experience with Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comRash and diarrhea were the most common side effects associated with Tarceva. They were generally mild to moderate. In large clinical studies, severe rash occurred in 9% of patients and severe diarrhea occurred in 6% of patients. You may also have other changes in your skin.
Related QuestionsWhat can I do if I experience a rash when taking Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comA rash may appear on your skin within 8-10 days of starting Tarceva therapy, most likely on your upper body or head. It may look like acne or dry skin, but it is not acne. Avoid acne-related treatments, including products with benzoyl peroxide. Rash is a common reaction to Tarceva. If you get a rash, do not stop taking Tarceva unless your doctor instructs you to do so. Try using a mild soap to wash areas affected by the rash, moisturize the area with a mild lotion and avoid sun exposure.
Related QuestionsWhat other important information should I know about Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comAll drugs have the possibility of causing some side effects. Some rare, but possibly serious, side effects may occur with Tarceva. In large clinical studies, there were infrequent reports of a lung injury known as Interstitial Lung Disease (ILD) and have included fatalities. Tarceva may cause liver problems. Let your doctor know if you have a history of liver disease. Women should also avoid becoming pregnant or breastfeeding while taking Tarceva.
Related QuestionsWhere can I find insurance coverage information for Tarceva?
Lung Cancer Frequently Asked Questions - Tarceva.comPatients will need to speak with their insurance provider to determine if Tarceva is covered. Each provider will respond differently. However, Medicare supplemental drug plans do provide coverage for Tarceva for advanced non-small cell lung cancer.
Related QuestionsHow long has Tarceva been available for NSCLC?
Lung Cancer Frequently Asked Questions - Tarceva.comThe Food and Drug Administration (FDA) approved Tarceva for advanced Non-Small Cell Lung Cancer on November 18, 2004. For more information see the FDA Approval Letter.
Related QuestionsAre there any potential drug interactions with Tarceva?
Resources - Frequently Asked Questions - Tarceva.comThe potent CYP3A4 inhibitor ketoconazole has been shown to increase erlotinib AUC; thus, caution should be used during co-treatment with Tarceva and ketoconazole or other CYP3A4 inhibitors such as, but not limited to: atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO) and voriconazole.
Related QuestionsWhat are the most common adverse events with Tarceva?
Resources - Frequently Asked Questions - Tarceva.comTarceva has no known contraindications, and its safety profile has been established in more than 2,000 patients in completed clinical trials. In the single-agent NSCLC Phase III trial, the most common side effects-rash and diarrhea-were generally mild to moderate. Each resulted in treatment discontinuation in 1% of Tarceva-treated patients.
Related QuestionsWhat are the important warnings and precautions with Tarceva?
Resources - Frequently Asked Questions - Tarceva.comThere have been infrequent reports of serious Interstitial Lung Disease (ILD)-like events, including fatalities, in patients receiving Tarceva. The overall incidence of ILD-like events in Tarceva-treated patients from all studies was approximately 0.7%. In NSCLC, single-agent Phase III study incidence was 0.8%-the same as placebo. In pancreatic cancer, in combination with gemcitabine study incidence was 2.5% in the Tarceva plus gemcitabine arm vs 0.4% in the placebo plus gemcitabine arm.
Related QuestionsIn which types of NSCLC patients is Tarceva use appropriate?
Resources - Frequently Asked Questions - Tarceva.comTarceva is indicated for the treatment of patients with locally advanced or metastatic Non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen. In the pivotal clinical trial for NSCLC, there was a significant survival benefit for a large, unselected group of patients receiving Tarceva monotherapy. Tarceva significantly improved overall survival by 37% vs placebo in these pretreated NSCLC patients (HR=0.73; 95% CI=0.61-0.86; P<0.001).
Related QuestionsAre there insurance information resources available for Tarceva?
Resources - Frequently Asked Questions - Tarceva.comTarceva Access Solutions provides coverage and reimbursement support, patient assistance and informational resources for both health care providers and their patients. You can access Tarceva Access Solutions on the Internet at www.TarcevaAccessSolutions.com or call the toll-free support line at 1-888-249-4918. If uninsured or financially challenged patients need help covering the cost of Tarceva, the experts at Genentech Access Solutions can help them with this issue.
Related QuestionsAre there other Tarceva clinical trials available for patients with advanced NSCLC?
Lung Cancer Frequently Asked Questions - Tarceva.comYou can find information on additional clinical trials of Tarceva (erlotinib) by visiting ClinicalTrials.gov
Related QuestionsHow does it work?
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