There are currently only two types of EB that are considered lethal. The first is Junctional Herlitz, which is often deadly to newborns. Junctional Herlitz effects internally, including the airway and other internal organs causing major complications. Many with this form pass away within a few weeks of birth.  The other form is RDEB-HS (the kind I have).

Epidermolysis Bullosa, or EB for short, is the name given to a group of rare genetic blistering skin disorders. EB causes the skin to be so fragile that even minor rubbing can cause blistering. In severe EB, daily bandage changing is required to treat the many open wounds and blisters. EB can also effect other areas such as the eyes and internally such as the mouth, esophagus, stomach, intestines, upper airway, bladder, and genitals. The skin is made up of many layers.

Of these, less than 300 have the same form of EB that I was born with. (Recessive Dystrophic - Hallopeau Siemens Epidermolysis Bullosa.) Only one in a million babies are born with the Recessive Dystrophic form of EB (RDEB). I prefer to say I'm one in a million  :o)

Most people with EB have inherited the condition through genes they have received from one or both parents. The faulty genes cause structural abnormalities in the skin. Genes govern the formation of different types of protein in the skin, including collagen and keratin. When any of these proteins is bad, the skin becomes so fragile it can literally fall apart.

Some forms of EB are dominant, some are recessive and some are spontaneous mutations (abnormal changes in a gene that occurred during the formation of the egg or sperm) In dominant forms of EB, the disease gene is inherited from only one parent who has the disease and there is a 50% chance with each pregnancy the baby will have EB. In the recessive forms, the disease gene is inherited from both parents. Neither parent shows signs of the disease, they are just carriers of the EB gene.

By doing a skin biopsy (taking a small sample of skin and examining it under a microscope), a dermatologist can identify where the skin separation occurs and what form of EB the person has. One diagnostic test involves use of a microscope and reflected light to see if proteins needed for forming connecting fibrals, filaments or hemidesmosomes are missing or reduced in number.

There is currently no cure for EB. At this time the best hope is gene therapy. In 1993 the gene that causes Dystrophic EB was located. That was the first major step. More advances are being made every year giving much hope for the future. Scientists are currently testing the delivery of modified cells to genetically altered mice that have EB traits.

In 1886, Kobner introduced the name epidermolysis bullosa hereditaria to describe a multigeneration affected family with mildly generalized, predominantly acral, serous blistering. This name is still widely used today. During the end of the nineteenth and beginning of the twentieth centuries, other famous dermatologists, including Brocq and Hallopeau, continued to group these patients under such terms as congenital traumatic pemphigus, congenital traumatic blistering, or acantholysis bullosa.

Thankyou for taking the time to learn about Epidermolysis Bullosa. Please help spread awareness and pass this site onto others. No, not at all, in fact most with EB excel in school. EB children can be mainstreamed into regular classes with the other kids. Some severe forms of EB cause the person/child to look much younger than they actually are, however don't let this fool you! In some forms of EB the skin does get better with age, in some cases dramatically better.

Yes. The drugs manufactured now are greatly increasing the life expectancy of those living with HIV/AIDS, but there is still no cure.

Both killer bees and fire ants attack en masse when disturbed. They can both cause fatal allergic reactions, in susceptible individuals. Africanized bees can overwhelm and kill even healthy, non-allergic people, but encounters are rather rare. Fire ants can't overwhelm a healthy, mobile person and even hundreds of stings are rarely fatal.

Exposure of 100 roentgens causes radiation sickness while exposure to 400 roentgens causes radiation sickness and death in half of those exposed, and 100,000 rads causes almost immediate unconsciousness and death within an hour.

Some dinosaurs were very lethal, as they were hunting carnivores, like lions and tigers are today, but much larger!

Not likely. Everybody reported to have been "poisoned" with GHB has "fully recovered," even a man who took 15 tablespoons (50-75 gm). There have been no long-term consequences identified in any of these cases despite close observation by attending physicians. It is exceedingly difficult to ingest the 50 to 150 gm that might threaten life. In high doses, for example, GHB causes nausea and vomiting, which strongly limits the maximum amount that a person can consume.

This is kind of like comparing apples to oranges. They both attack en masse and can both cause fatal allergic reactions, but that's where the similarities end. Africanized bees can overwhelm and kill even healthy non-allergic people, but encounters are rather rare. Fire ants can't overwhelm a healthy, mobile person and even hundreds of stings are rarely fatal. But, fire ant mounds are extremely common.

We don't think so, because cardiac pacemakers are well insulated. In addition, the manufacturers are required to perform extensive testing in this regard. First, you would have to be very sure that you didn't leave any skin uncovered, because the human body is as electrically conductive as a sack of salty water. The current would spread from an uncovered wrist, ankle, or neck to a very wide area.

Non-lethal is a term used by the military (mostly aligned to NATO) and in United Nations' documents. Tends not to be used by law enforcement agencies. A strict interpretation of the term implies a weapon, system or technology designed with the intent of not causing serious injury or death.

The term "Non-lethal Weapon" has evolved to include more than what are traditionally thought of as crowd control devices. They include a broad range of technologies designed to modify an individual's motivation or behavior (e.g., single aggressors and barricaded suspects), manage crowds (e.g., non-compliant groups and serious public disorder), support custody/corrections operations (e.g., prisoner disorder and prison riots), and conduct specialized operations (e.g.

We are authorized to use this, but choose not to. Lethal baits are reliable, but not species specific so we find this too great a risk. Bait consumption can't be controlled so we don't know what birds will die and where they will die. There is a new product coming on the market that does not kill the birds, but sterilize the eggs so they do not hatch. We are researching the effects of this product and may selectively add this to our offering in the future.

loz; SAQ ◊ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Well, it is possible to eat it safely. After you've tried the raw octopus (tako), eel (unagi), squid (ika), and cuttlefish (kouika), why not have some blowfish (fugu)? The diodon holacanthus contains the deadly poison tetrodotoxin (TTX), a neurotoxin that blocks the sodium channel in your nerves.

The LD50 of Diphenhydramine in rats is 500mg/kg. For humans it is not known, so be careful! Lethal doses in humans are almost always far less than lethal doses in rats (allowing for body weight differences), so don't try to take the rat LD50 and apply it to yourself. Also, note that the LD50 is the dose at which 50% of the subjects will die. A lower dose will still kill a smaller proportion of the subjects - i.e. it may be that the LD10 (i.e. 10% mortality) for rats is just 100 mg/kg.

The LD50 (dose at which 50% of animals die) of DXM doesn't seem to be well known. For a variety of reasons, animal assays of the lethal dose of psychoactives aren't always accurate. Nor have I ever found a published LD50 for DXM. So instead, I've decided to go on the basis of the few deaths that have occurred from DXM use, keeping in mind the amount of DXM people regularly consume for recreational purposes.

Recently the news carried the story that a researcher had discovered that taking vitamin E at a level of 400IU or more increases the risk of death. (Jan 2005, Annals of Internal Medicine http://www.annals.org/content/vol142/issue1/) I was... It is never too late to be what you might have been. "(George Eliot) I have found that truly successful people surround themselves with the support that makes them excel. Over years of working with clients I have found that people struggle..

Much controversy surrounds this question. As little as 20 mg (substantially less than a single line) injected intravenously can be lethal while between 500mg and 1.4 g nasally or orally is considered dangerous. Purity, mixing with other substances (especially heroin), environment, and the individual are all factors. It is not recommended to rub cocaine on any exposed tissues or the mucous membranes of the genitals.

If a patient or agent decides to refuse ordinary treatment or care in order to bring about the patient?s death, in some instances there may be little that a medical professional can do to prevent this. However, there remains the duty to attempt to persuade the patient/agent otherwise or, failing that, for the physician or other care provider to remove himself/herself from the case in order not to be guilty of complicity in euthanasia.

Correction. IF you tie a piece of toast to a cat's back. Have you ever TRIED tying a piece of toast to a cat's back? If you've ever actually been successful in this little endeavor, take a picture for me, and I'll answer the question. Better yet, YOU answer the question, since you have your little science experiment right in front of you.

The dew's claw is a claw which is no longer used and which still contains bones in some dogs, but only consists of skin and claw in others. The claw has no function, but the dog can hurt himself on it in some circumstances. Therefore, this claw is generally removed by a small operation. If the dog is chewing on them, then these claws bother him. He cannot die from this but the claws can become infected and have to be treated. Bring your dog to a vet.

No, it’s possible to torture an animal to death with any euthanasia method when not properly performed. Departments must budget to train staff in certified classes and, as in all job duties, provide consistent oversight and support to ensure humane protocols are followed and compassionate ethics employed. [xvi]