CML is shorthand for chronic myeloid, chronic myelocytic or chronic myelogenous leukemia (also known as chronic granulocytic leukemia or cgl) CML is a form of leukemia which affects the cells which make granulocytes (the polymorphs that eat bacteria) and the platelets (the little cells which help the blood to clot). In its early stages it produces an increase in the numbers of granulocytes and platelets but these cells still function normally and the patient may have no symptoms.

CML is generally considered in patients with an elevation in blood granulocyte concentration if the explanations of infection and inflammation aren't likely. The differential diagnosis includes the other myeloproliferative disorders, myelofibrosis, polycythemia vera, other causes of leukocytosis (inflammation or infection).

Leukemia strikes both sexes and all ages. Causes of most cases are unknown. Persons with Down syndrome and certain other genetic abnormalities have higher than normal incidence of leukemia. It has also been linked to excessive exposure to ionizing radiation and to certain chemicals such as benzene, a commercially used toxic liquid that is also present in lead-free gasoline. Certain forms of leukemia and Lymphoma are caused by a retrovirus, HTLV-I (human T-cell leukemia/lymphoma virus-I).

CML is chromosomal/genetic but not hereditary. This means it is not caused by a gene being passed on. During the patient's lifetime, they somehow were exposed to something which damaged their genes. This resulted in the translocation of the 9 and 22 chromosome, and led to CML. However, there are familial incidences among 2 or more family members in other myeloproliferative disorders so the answer is not clear.

For many years, the only treatment for CML was palliation with the drug busulfan (a drug that reduces the number of white cells and platelets as well as red cells but does not slow down progression of the disease. Hydroxyurea was also used for this purpose. Then it was found that interferon-alpha can control CML in about 80% of patients and reduces the Philadelphia chromosome in about 40%.

Gleevec (STI571) was originally developed to inhibit a particular enzyme (tyrosine Kinase) which is produced by the Bcr-Abl oncogene and is believed to drive the unregulated production of white blood cells. The Bcr-Abl oncogene is present in 95% of CML (Chronic Myelogenous Leukemia) patients and about 20% of ALL (Acute Lymphoblastic Leukemia) patients.

Without interferon or a transplant the life expectancy has historically been 3 to 5 years after diagnosis. Interferon has been proven to significantly increase life expectancy and the combination of interferon and ARAC is believed to be superior to interferon alone. Autologous marrow or stem cell transplants, likewise, if successful engraftment takes place, extend life expectancy, but since the immune system has not been replaced (as with a donor transplant) are not currently curative.

Please contact your local representative for the appropriate Material Data Sheet for any CML package style. Your first contact point should be your local representative or distributor, their details are available elsewhere on this website. Please ensure the requirement for RoHS compliant (Pb-Free) products is detailed on all purchase order paperwork. All Pb-free shipping materials will clearly be labelled as Pb-free with either e2 or e3 labels as shown in Fig.1 below.

The CML figure is the Council of Mortgage Lenders figure and, put simply, the more money being lent to buy homes, the more confident people are of their own finances and the more they are likely to spend, so boosting economic activity in general. This can also be affected, of course, by remortgaging activity, which can slightly cloud the figures ! What is important to markets is the NET lending figure.

The previous response gives information on the synchronous/asynchronous conversion required. The other consideration is level translation. RS232 typically uses +/- 12V for its signalling levels, these must be translated to 5V an 0V for CML modems. Further, the idle state on RS232 is a continuous mark (or binary 1) represented by -12V. The corresponding logic level for a mark is 5V(high), RS232 therefore requires inverting. The most common device used for this translation is the Maxim MAX232.

A component or assembly shall be defined as containing no Pb when the Pb content of the device is less than 0.1% by weight and is not intentionally introduced. This definition is in accordance to IPC/EIA J-STD-006.

CML has made available a large number of characterisation factors, for climate change, ozone depletion, human toxicity, ecotoxicity, acidification and so on. To import the list, download and run the MS-Excel file that is posted at the website with characterisation factors (click here). Move to the table of contents, and press one of the two "Export" buttons: the first one to export the characterisation factors, the second one to export the normalisation data.

A2) Novartis sees the program as a true alliance between healthcare providers, patients, and Novartis, dedicated to optimizing therapy in all Ph+ CML patients worldwide.

All CML devices, with the exception of the MX029 and MX128, use an internal voltage divider between VDD and VSS to derive the VBIAS voltage. This reference voltage can be "pulled" rather easily with resistive loading on the VBIAS pin, therefore minimal resistive loading is suggested (250KOhm should be adequate). If it is desirable to use the VBIAS reference, VBIAS should connect directly to a voltage-follower buffer amplifier first.

Yes. Connect one oscillator as normal. Connect the oscillator out (usually marked XTAL or XTALN) to the clock input (usually marked XTAL/CLOCK).

CML has introduced a RoHS Compliant, Lead-free (Pb-free) Program in response to legislation calling for companies to utilize Pb-free manufacturing processes and components. Also, many of our customers are requesting products that utilize Pb-free manufacturing processes and components.

CML is working together with several industry consortia and forums to offer RoHS compliant (Pb-free) product alternatives. CML is working with its suppliers and customers to offer RoHS Compliant (Pb-free) products.

CML has qualified the following Pb-free composition: Sn 96%, Ag 3.5% and Cu0.5%. At this time, we have no specific plans to qualify any other solder types.

Schools and parents can order but only by mail as we do not accept credit card orders by phone or online. Here is how the books can be ordered: Use our application form (you can download it from the CML page on our site) or write us a note telling us which book(s) you wish to order. If you are a parent please enclose a check payable to the CML for the cost of the books (PO's are accepted from schools).

A10) For general information about the program, please visit the global CML Alliance website at CMLAlliance.net. For specific enrollment into the program, please contact your local Novartis office. Enrollment in CML Alliance is voluntary. Healthcare providers and patients are under no obligation to enroll or maintain their participation in the program.

A15) Patients treated with Glivec® as first-line therapy tend to achieve high overall rates of complete hematologic and cytogenetic response.3 The degree of Glivec® efficacy was therefore explored by measuring trace levels of Bcr-Abl transcripts4(molecular response) to assess whether a patient with Ph+ CML has achieved or is trending towards a desired response to therapy and to ensure that a patient’s treatment is optimized over time.

A17) For specific information and services available in each country, please contact your local Novartis organization. Where permissible under local laws and regulations, CML Alliance will offer PCR testing in certified laboratories with significant expertise in PCR, based on a standardized molecular monitoring and reporting standards for PCR testing so that physician can have access to consistent and easily interpretable PCR results for better management of Ph+ CML patients.

SDF is already a defacto industry standard for data exchange between chemical relational database and modeling applications. It is a public standard with a very simple ASCI II text format and flat field structure (i.e., no nested fields within fields). More on SDF Neither XML nor the chemically-inclusive version, CML (Chemical Mark-up Language), is at present completely standardized or in common use in chemical database or modeling applications.

A 260°C solder reflow profile can be used for all Pb-free devices please see attached link: Solder Profile

Yes, but you must do so with caution, and remember, CML does not guarantee the performance of its devices when operated outside of their specified parameters. In general, when a CML device is operated with a non-recommended crystal frequency, all of the device parameters scale in direct proportion to the change in crystal frequency.

CML have several devices that can comply to the Bell202 specification: FX614 / CMX624 / CMX850 / CMX866 / CMX867 / CMX868 / CMX869 / CMX878 The FX614 is a very popular device which is used as a suitable replacement for the TCM3105. The FX614 offers a cheap and simple solution to wire-line & radio modem applications.

Yes, you can access the CML online by visiting: CML Online Directory where you can search for listings or update your information. You may also update your information by contacting Member and Customer Services as follows: