The LD50 of Diphenhydramine in rats is 500mg/kg. For humans it is not known, so be careful! Lethal doses in humans are almost always far less than lethal doses in rats (allowing for body weight differences), so don't try to take the rat LD50 and apply it to yourself. Also, note that the LD50 is the dose at which 50% of the subjects will die. A lower dose will still kill a smaller proportion of the subjects - i.e. it may be that the LD10 (i.e. 10% mortality) for rats is just 100 mg/kg.

Antihistamines generally, and Diphenydramine Hcl specifically, act by antagonizing histamine at the site of the H1 histamine receptor. Antihistamines dry up the secretion of the nose, throat, and eyes. They relieve itch and will help you go to sleep. Dimenhydrinate depresses the middle-ear function, but the way in which it actually prevents nausea, vomiting, or dizziness is not known. However, these drugs are not just antihistamines. They have a significant amount of anticholinergic activity. See similar questions...

The LD50 (dose at which 50% of animals die) of DXM doesn't seem to be well known. For a variety of reasons, animal assays of the lethal dose of psychoactives aren't always accurate. Nor have I ever found a published LD50 for DXM. So instead, I've decided to go on the basis of the few deaths that have occurred from DXM use, keeping in mind the amount of DXM people regularly consume for recreational purposes. See similar questions...

Yes. The drugs manufactured now are greatly increasing the life expectancy of those living with HIV/AIDS, but there is still no cure. See similar questions...

Exposure of 100 roentgens causes radiation sickness while exposure to 400 roentgens causes radiation sickness and death in half of those exposed, and 100,000 rads causes almost immediate unconsciousness and death within an hour. See similar questions...

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Do not stop taking the medication without talking to your doctor. Please refer to the Metoprolol Succinate Extended-release Tablets Product Insert Sheet for additional information. See similar questions...

Since food substantially increases the bioavailability of erlotinib and may increase the risk of adverse events, patients should be instructed to take Tarceva at least one hour before or two hours after the ingestion of food. The degree that food increases the bioavailability of erlotinib may vary; therefore, Tarceva tablets should be taken on an empty stomach to help ensure that patients obtain consistent plasma levels of the drug. See similar questions...

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. See similar questions...

While we recommend that you talk to your physician first, Gaviscon® Acid Breakthrough Formula is perfectly safe to take with your prescription heartburn medication. See similar questions...

UV dose is the energy that is coming off the UV lamp over a specific time period. Therefore, UV dose (or fluence) is a product of UV intensity and time. Dose is usually measured in milli joules per square centimeter. Each Sterilight system is rated to disinfect your water at specific flowrate, under specific water quality conditions to give a UV dose of 30 mJ/cm2 at the end of the lamp life (which is one year). If you were to run say 10 USGPM through a 5 USGPM Sterilight system (ie. See similar questions...

Flora Balance is safe at higher doses. Dr. Corsello in her booklet “Bacillus Laterosporus BOD…” suggests doubling the dose to 2 capsules or 1 teaspoon of powder morning and night. We recommend that you begin at the suggested therapeutic dose of 2 capusles or 1 teaspoon of powder / day for a week or so before considering increasing your dose of Flora Balance. See similar questions...

Phenterprin HCL is an extremely powerful pharmaceutical-grade oral appetite suppressant created for those who are significantly overweight. It helps you feel less hungry while giving you more energy. The recommended initial dose for Phenterprin HCL in 30mg capsules is to start with one Phenterprin HCL 30mg capsule per day. Your doctor can best determine the appropriate dose for you. See similar questions...

Not likely. Everybody reported to have been "poisoned" with GHB has "fully recovered," even a man who took 15 tablespoons (50-75 gm). There have been no long-term consequences identified in any of these cases despite close observation by attending physicians. It is exceedingly difficult to ingest the 50 to 150 gm that might threaten life. In high doses, for example, GHB causes nausea and vomiting, which strongly limits the maximum amount that a person can consume. See similar questions...

This is kind of like comparing apples to oranges. They both attack en masse and can both cause fatal allergic reactions, but that's where the similarities end. Africanized bees can overwhelm and kill even healthy non-allergic people, but encounters are rather rare. Fire ants can't overwhelm a healthy, mobile person and even hundreds of stings are rarely fatal. But, fire ant mounds are extremely common. See similar questions...