Unfortunately, we cannot provide interviews and we do not provide the contact information of others. However, our Medical Director has helped create this Q and A and all other information on Progeria that appears on this site, so perhaps that is sufficient to satisfy the interview requirement for your report.

Autosomal Dominant genes express themselves when present. Autosomal Recessive genes will only express themselves when in the homozygous state -- i.e., both genes in the gene pair are the recessive gene form. Thus, recessive genes can be "carried" by those whose phenotype does not exhibit the gene characteristic, while dominant genes cannot be "carried". See similar questions...

Hutchinson-Gilford Progeria Syndrome (“Progeria”, or “HGPS”) is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. Its name is derived from the Greek and means "prematurely old." While there are different forms of Progeria*, the classic type is Hutchinson-Gilford Progeria Syndrome, which was named after the doctors who first described it in England; in 1886 by Dr. Jonathan Hutchinson and in 1897 by Dr. See similar questions...

Heterozygous, homozygous, recessive, co-dominant and dominant are terms used to describe genetics or traits. You will hear and see these terms quite frequently when discussing ball python morphs. Let's take an Albino ball python for example. It is a homozygous ball python because it received the Albino gene from both its mother and father. A het (heterozygous) Albino will contain one and only one Albino gene from either the father or mother. See similar questions...

Although genetic testing is the only "full proof" way to tell which version of FEVR a person has, a family survey can sometimes eliminate the options. X-linked for example, runs only in the males of the family so if a girl in the family has FEVR you know it is either dominant or recessive. In Dominant families the disease tends to show up in many generations. Recessive is more rare than dominant. of yet, no test for the recessive or dominant gene exists. See similar questions...

Most people underestimate just how many babies are being born damaged. 48,000 babies each year are born with Birth Defects. That is, 3% of live and still births will have a serious birth defect and a further 3% some minor abnormality... Hereditary hemochromatosis, once thought to be rare is the most common genetic disorder in the United States. Nonetheless, the condition often goes undetected and untreated until... http://www.eyesight. See similar questions...

conditions require that an individual with the disease inherits two deleterious mutations in the same gene, one from each genetic parent. Carriers have just one abnormal mutation and are not affected. Currently most people do not know whether or not they are carriers. Family genetic and medical history is of limited value in assessing the risk of AR diseases because the chance of a match between two carriers for CF is only 1 in 841. See similar questions...

Progeria has a reported incidence of about 1 in 4 - 8 million newborns. It affects both sexes equally and all races. In the past 15 years, children with Progeria have been reported all over the world, including in Algeria, Argentina, Australia, Austria, Canada, China, Cuba, England, France, Germany, Israel, Italy, Mexico, the Netherlands, Poland, Puerto Rico, South Africa, South America, South Korea, Switzerland, Turkey, the US, Venezuela, Vietnam and Yugoslavia. See similar questions...

Although they are born looking healthy, children with Progeria begin to display many characteristics of accelerated aging at around 18-24 months of age. Progeria signs include growth failure, loss of body fat and hair, aged-looking skin, stiffness of joints, hip dislocation, generalized atherosclerosis, cardiovascular (heart) disease and stroke. The children have a remarkably similar appearance, despite differing ethnic backgrounds. See similar questions...

HGPS is caused by a mutation in the gene called LMNA (pronounced, lamin – a). The LMNA gene produces the Lamin A protein, which is the structural scaffolding that holds the nucleus of a cell together. Researchers now believe that the defective Lamin A protein makes the nucleus unstable. That cellular instability appears to lead to the process of premature aging in Progeria. PRF was the driving force behind finding the gene responsible for Progeria. See similar questions...

Now that the gene mutation has been identified, The Progeria Research Foundation has created a Diagnostics Testing Program. We can now look at the specific genetic change, or mutation, in the Progeria gene that leads to HGPS. After an initial clinical evaluation (looking at the child’s appearance and medical records), a sample of the child’s blood will be tested for the Progeria gene. For the first time ever, there is a definitive, scientific way to diagnose the children. See similar questions...

It doesn't. It attempts to express both alleles. In cells with dominant mutations, two proteins will be produced. There are a number of mechanisms by which the abnormal protein can cause the phenotype even in the presence of the healthy protein. For example some connective tissue proteins form polymeric chains. The chain will consist of proteins from both alleles and as we all know, a chain is only as strong as... See similar questions...

Children with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, one of the leading causes of death worldwide.+ As with any person suffering from heart disease, the common events for Progeria children are high blood pressure, strokes, angina (chest pain due to poor blood flow to the heart itself), enlarged heart, and heart failure, all conditions associated with aging. See similar questions...

HGPS is not usually passed down in families. The gene change is almost always a chance occurrence that is extremely rare. Children with other types of “progeroid” syndromes which are not HGPS may have diseases that are passed down in families. However, HGPS is a “sporadic autosomal dominant” mutation. See similar questions...

Make a financial contribution. Donations are needed to continue the vital work of PRF. No donation is too little or too big – every dollar counts in our fight for a cure! Donate your time. Volunteers are also important to PRF’s success. See similar questions...

The Progeria Research Foundation funds medical research aimed at developing treatments and a cure for Progeria. PRF also has its own Cell & Tissue Bank that provides the biological materials researchers need to conduct their experiments. The PRF Cell & Tissue Bank was instrumental in the recent discovery of the Progeria gene. Cell lines from the PRF Cell Bank were essential to the experiments that led to the Progeria gene discovery. See similar questions...

Most breeds of dog have one (or several) dominant traits, usually ones related to the breed's purpose of function. For example, German Shepherds have a strong instinct to herd which often shows in herding people, sometimes even nipping at their heels to get them to move. This is due to the fact that the breed originated as a working herding breed, and dogs with strong herding instinct were naturally bred more (to keep this instinct in the breed) than dogs with low drives. See similar questions...

The concepts of “dominance” and “alpha” were originally incorrectly applied to dogs. These concepts came about as the result of studies on captive wolves. While dogs have descended from wolves, they are NOT wolves. They are domesticated dogs. See similar questions...

We deal with both commodity and specialty chemicals. Please review the list of Commodity and Speciality chemicals, that we deal in. Some of the commodity products which we are dominant are in the oil drilling industry, paint & coating industry, and adhesives and sealants industry. See similar questions...