The 5% Xandrox solutions are sufficiently effective on most parts of the scalp for most patients. Xandrox 12.5% should only be used on those parts of the scalp which are stubborn in responding to 5% Xandrox. Save money and only use the Xandrox 12.5% lotion where directed. It's a powerful drug. Use it sparingly. That's right. The large bottle of 12.5% Xandrox is five ounces in size. Slightly more than four ounces are put into the bottle.

The effect of minoxidil on hair follicles is dose dependent. Xandrox 12.5% Lotion has been successful in halting and/or reversing MPB in cases where other therapeutic measures have not worked well. There appears to be a threshold level at which some hair follicles will become responsive to minoxidil in regenerating terminal hairs. See similar questions...

It's a matter of dosage and safety. Even 5% minoxidil solutions have been known to cause rare side effects such as dizziness and headaches. The most innocuous substances can be harmful in large doses. For example, vitamin A is essential to good health. Hypervitaminosis A causes bone pain and hair loss. See similar questions...

Optimally, yes. The Xandrox 12.5% lotion is meant to be used as a supplement and not a replacement for the use of 5% Xandrox. The Xandrox 12.5% lotion should only be used in areas unresponsive or poorly responsive to 5% Xandrox solutions. See similar questions...

Xandrox 12.5% Lotion is an exclusive formulation by Dr. Lee of topical 12.5% minoxidil and 5% azelaic acid with an absorption enhancer. It has been designed for the treatment of MPB, is trade marked, and there is a patent pending on it. See similar questions...

Minoxidil is soluble in alcohol bases only to a maximum concentration of 5%. Xandrox 12.5% is an opaque, white lotion. See similar questions...

Because the concentration of minoxidil is so high, we suggest that no more than 1 mL of Xandrox 12.5% be used per day. The 30 mL bottles of Xandrox 12.5% have treatment pumps that dispense ~0.25 mL of lotion with each complete depression of the pump. The 125 mL bottles of Xandrox 12.5% dispense ~1.0 mL with each full depression of the pumping spout. See similar questions...

Only on those areas of the scalp that are refractory to treatment of MPB by any other means. For most patients, this means the areas of both temples and/or the frontal hairline. But some patients will want or need to use it in the vertex and/or on the crown. It should not take the place of 5% Xandrox for general application on other parts of the scalp. See similar questions...

Unfortunately, after almost two decades of use and evaluation, it is obvious that minoxidil solutions used alone have not been significantly effective for reversing MPB for the majority of patients. However, when minoxidil is combined with an inhibitor of 5-alpha reductase, the majority of patients will have positive visible results in growing scalp hair See similar questions...

Benzyl nicotinate. It is chemically related to niacin and can cause a temporary 'flushing' of the scalp where it is applied. The 5% Xandrox does not need an absorption enhancer because it has an alcohol base. Minoxidil in a 12.5% concentration is not compatible with a base that is primarily alcohol. Therefore an absorption enhancer was incorporated into the Xandrox 12.5% formula to make the absorption rates equivalent. Not necessarily. See similar questions...

Unfortunately, no. By definition, idiosyncratic reactions are peculiar to the specific patient. Rare, mild side effects related to lowered blood pressure have been reported by test subjects. At any time of the 24 hour cycle when it can best be left undisturbed on the scalp for the longest period of time. Since the lotion becomes virtually invisible within minutes of application, it can be applied at any time of day. See similar questions...

Since the Xandrox 12.5% is recruiting previously unresponsive hair follicles to grow again, these hairs will first have to be shed. The follicle will remain inactive during the ~100 days of telogen, and will then grow back thick enough so that you can appreciate the difference. This process usually takes a minimum of 4 to 6 months. See similar questions...

Yes, it can, but the amount of increased shedding is usually imperceptible. Hair that is approaching the telogen phase, or is already in the telogen phase, is prompted to shed earlier than usual due to the use of minoxidil. Rarely will much more than 10% of the hair be in the telogen phase at any given time. This means that under the worst-case scenario, approximately 10% of one's hair would be shed. If this does happen, most patients will not even notice the process. See similar questions...

Absolutely not. That is not to say that there haven't been patients who have experienced shedding after using minoxidil and/or azelaic acid. On a purely statistical basis, there will be and have been patients who shed a lot of hair shortly after using Xandrox 12.5% lotion, but there is no sound medical evidence to show a direct 'cause and effect'. See similar questions...

Retinoic acid is a very powerful drug with some undesirable side effects. Some patients cannot tolerate its use or would rather not put up with the undesirable side effects. The absorption enhancer in the Xandrox 12.5% makes the addition of retinoic acid unnecessary and allows the Xandrox 12.5% to be used at any time of the day or night. See similar questions...

It is Dr. Lee's exclusive formulation in which a 5 % minoxidil solution is combined with 5% azelaic acid, a topically effective inhibitor of 5-alpha reductase, and the anti-inflammatory agent, betamethasone valerate. The Xandrox solutions are available with and without the addition of 0.025% retinoic acid. See similar questions...

Although retinoic acid does allow for better absorption, that is not its only reason for being in the 5% night formula. Retinoic acid encourages rapid cell division. Rapid cell division can lead to larger follicles which are capable of producing thicker hair shafts. See similar questions...

Not at all. Using one's fingertips and with minimum massaging, the lotion disappears almost immediately into the scalp. There is almost no visible residual on the skin or hair. This is due to one of our most valuable secrets in its formulation. The lotion changes its physical properties so absorption and penetration occurs when activated by normal body heat. It shouldn't be a problem. Xandrox 12. See similar questions...

The pumps must be primed in order to function correctly. If priming them in the bottle takes too long, prime them in water, and then affix them to the bottle. The first depression of the pump will produce water, but thereafter lotion will be dispensed. If proper priming does not work, your lotion has almost certainly been subjected to excessive heat. Please see FAQ's above, for possible correction of heat-related problems. See similar questions...

Again, it's not necessary, but it's more effective. Topical minoxidil is dose related. Using Xandrox containing 0.025% retinoic acid allows for better penetration and enlarges the follicles from which the hair shafts grow. Recent reports even suggest that chronic use of topical retinoic acid reduces the number of androgen receptors on the hair follicles by 30% or more See similar questions...