Buprenorphine is metabolized by cytochrome P-450 3A4 isoenzymes. It is important to carefully monitor SUBOXONE patients who are taking medications that inhibit or induce CYP-450 3A4 isoenzymes. SUBOXONE patients may require a dose reduction if CYP 3A4 inhibitors such as azole antifungal agents (eg, ketoconazole), macrolide antibiotics (eg, erythromycin), or HIV protease inhibitors (eg, ritonavir) are coadministered.

Taken on its own, SUBOXONE has lower potential for fatal overdose than a full opioid agonist because it has a limited effect on reducing breathing. Taking more SUBOXONE does not affect breathing as much as full opioid agonists can, so it is less likely to cause death in cases of accidental or deliberate overdose when taken in the absence of benzodiazepines, sedatives, tranquilizers, antidepressants, or alcohol. See similar questions...

It is possible to switch to SUBOXONE from methadone treatment, but because everyone's situation is different, switching should first be discussed with your doctor. See similar questions...

The length of your SUBOXONE treatment depends on what your doctor, you, and, possibly, your counselor or therapist decide is best for your needs. Although short-term treatment may be an effective option for some, for others it may not allow enough time to address the psychological and behavioral aspects of their condition. The chance of relapsing can be higher with short-term treatment because patients have less time to learn the skills needed to maintain an opioid-free lifestyle. See similar questions...

Doctors need to be certified to prescribe SUBOXONE. Doctors who are already specialists in addiction medicine or who complete specific training can become certified to treat opioid dependence with SUBOXONE in their offices. Ask your doctor if he or she is certified. If not, your doctor may elect to become certified so that he or she can treat you, or opt to refer you to a colleague who is certified. See similar questions...

SUBOXONE can reduce respiratory rate. However, because buprenorphine is a partial opioid agonist, when taken alone it exhibits a ceiling dose beyond which no greater effect is observed on physiologic or subjective measures.8 This "ceiling effect" on respiratory depression—unlike full opioid agonists where respiratory depression continues increasing as the dose increases—means SUBOXONE by itself is unlikely to cause death in the event of an overdose. See similar questions...

YES. There is benzphetamine (Didrex) which is metabolized to d-methamphetamine and d-amphetamine. Benzphetamine is used to treat weight loss. Selegiline also known as l-Deprenyl under the trade name Eldeprl is metabolized to l-methamphetamine and l-amphetamine. It is used for parkinsonism. There is another drug which is prescribed in Mexico but not in the U.S which is Clobenzorex (Asenlix) which is metabolized to d-amphetamine. It is used to treat weight loss. See similar questions...

It is important to be in mild-to-moderate withdrawal when you take your first dose of SUBOXONE. If you have high levels of another opioid in your system, SUBOXONE will compete with the other opioid molecules and knock them off the receptors. SUBOXONE then replaces those opioid molecules on the receptors, but because SUBOXONE has less opioid effects than full opioid agonists, you may go into withdrawal and feel sick. This is called precipitated withdrawal. See similar questions...

Intravenous misuse of buprenorphine, usually in combination with benzodiazepines or other CNS depressants (including alcohol) has been associated with significant respiratory depression and death. It can be dangerous to mix SUBOXONE with drugs like benzodiazepines, alcohol, sleeping pills and other tranquilizers, certain antidepressants, or other opioid medications, especially when not under the care of a doctor or in doses different from those prescribed by your doctor. See similar questions...

Buprenorphine is a medication used in treating people with narcotic problems. For more information visit: See similar questions...

Buprenorphine has been available as SUBOXONE in the United States since 2003. In Europe, buprenorphine was introduced during the mid-90s. Today, more than 400,000 opioid-dependent patients worldwide have been treated with buprenorphine. All opioids can cause physical dependence. SUBOXONE belongs to a class of opioids called "partial opioid agonists. See similar questions...

Both SUBOXONE and SUBUTEX feature buprenorphine—a partial opioid agonist that suppresses opioid withdrawal symptoms and cravings—as the primary active ingredient. (For more about buprenorphine, see Treatment Advantages of a Partial Opioid Agonist.) However, SUBOXONE also contains naloxone, an opioid antagonist, to help deter diversion and misuse (the ratio of buprenorphine to naloxone in SUBOXONE is 4:1). See similar questions...

with other medications in this class, the most commonly reported side effects for SUBOXONE include headache (36% vs 22% placebo), withdrawal syndrome (25% vs 37% placebo), pain (22% vs 19% placebo), nausea (15% vs 11% placebo), insomnia (14% vs 16% placebo), and sweating (14% vs 10% placebo). Please review the Important Safety Information that appears at the bottom of the screen. See similar questions...

SUBOXONE and SUBUTEX are both classified as Pregnancy Category C. There are no adequate and well controlled studies of SUBOXONE or SUBUTEX in pregnant women. SUBOXONE or SUBUTEX should be used during pregnancy only if the potential benefit to the patient justifies the potential risk to the fetus. See similar questions...

Chronic administration of SUBOXONE produces physical dependence of the opioid type. See similar questions...

a pharmacist, you are in a unique position to help local physicians implement office-based treatment of opioid dependence with SUBOXONE. One of the most valuable functions that you provide is counseling patients. Patient Counseling Checklist Special federal regulations apply to how you verify prescriptions for SUBOXONE. See similar questions...

Subutex? and Suboxone? are available in pharmacies throughout the United States. Pharmacies and physicians can obtain the medications by contacting a pharmaceutical wholesaler directly, or by contacting the drug manufacturer, Reckitt Benckiser, at 1-877-782-6966. Consumers may also call the same toll-free number for additional information. See similar questions...